Sarcomatoid mesothelioma is the least common histological type of mesothelioma, but it is the most aggressive.
http://www.ncbi.nlm.nih.gov/pubmed/20081811?dopt=Abstract
Even more than epithelial mesothelioma, the sarcomatoid form is difficult to diagnose and to distinguish from other diseases. Just looking at the cells under a microscope is not enough, and doctors employ immunohistological tests to distinguish Sarcomatoid mesothelioma from true sarcoma and pulmonary sarcomatoid carcinoma.
http://www.ncbi.nlm.nih.gov/pubmed/18199156?dopt=Abstract
The general treatment plan for sarcomatoid mesothelioma focuses on:
- Managing pleural effusions
- Administering radiotherapy to intervention sites
- Evaluating suitability for radical surgery
- Evaluating suitability for chemotherapy and clinical trial entry